Stem cell scientist offers hope
Dr David Nisbet
As a materials engineer, Dr David Nisbet is working in the field of tissue engineering and regenerative medicine. This area adopts an interdisciplinary approach using novel combinations of stem cell biology, biomaterials and nanotechnology. Specifically, he is working on neural tissue engineering and bone tissue engineering.
In the area of neural tissue engineering research, Dr Nisbet is investigating the feasibility of using biodegradable electrospun nanofibres and injectable hydrogels (synthetic and natural) for the repair of damaged neural pathways within the brain and spinal cord.
Dr Nisbet’s bone tissue engineering research involves the development of new biomimetic coatings for hip prosthesis’.
“I am developing new, tough coatings for the implants with the aim of improving mechanical and bone fixation properties,” Dr Nisbet said.
“The microstructure of the coating is based on that of physiological bone, with a combination of degradable polymer, biologically active nanoparticles and growth factors. Such microstructures are achieved using simultaneous electrospinning and electrospraying technologies. We then conduct in vitro screening of these coatings using a variety of different cell phenotypes, but most commonly Mesenchymal stem cells.”
Dr Nisbet has chosen this field of research because it is a niche area that will make a difference to humanity.
“On more of a personal note, I find the interdisciplinary nature of the work stimulating. I really enjoy learning about all the broad range of areas associated with my research.”
There is potential for much of Dr Nisbet’s research to result in patents and spin off biotechnology companies and/or products. However, he believes the major impact of his research will be on society, as it will assist with the treatment of neurodegenerative diseases such as Parkinson’s Disease; which is prevalent in our aging population.
“It can also offer hope to younger people with injuries such as spinal cord damage. For the bone project, better bone growth will result in superior fixation and eliminate the need for revision surgeries,” he said.