Aust Ctr for Blood Diseases

    Research areas

  • Apoptosis, Bcl-2, Myeloid leukaemia, Interleukin-3, GM-CSF

Biography

Anissa Jabbour completed her PhD in 2005 chatracterising the function of caspase inhibitors and has since undertaken three post-doctoral positions in the field of cell death before starting her own group at the Australian Centre for Blood Diseases (ACBD), Monash University. Dr Jabbour's primary research focus is how cell death and survival signalling cascades are regulated by cytokines, in particular Interleukin-3 (IL-3) and GM-CSF. Her laboratory is interested in how IL-3 and GMCSF signal cell survival and proliferation, and how these survival pathways are deregulated in Acute Myeloid Leukaemia.

Dr Jabbour's postdoctoral research investigated

  • The affect of TRAIL and known chemotherapeutics on ex vivo glioma specimens
  • The regulation of pro-apoptotic Bcl-2 protein Puma in myeloid cells
  • The role of the transcription factor p53 in initiating cell death in response to a non DNA damaging stimulus (loss of Interleukin-3) in myeloid cells

Dr Jabbour and her teams current primary research focus is to analyse

  • How cytokines, in particular, Interleukin (IL)-3 and GM-CSF regulate cell survival mechanisms
  • The role of the kinases JAK2, AKT and IKK play in maintaining cell survival in the presence of IL-3 or GM-CSF
  • The role IL-3/GM-CSF dependent pathways play in normal haematopoiesis and in disease, primarily Acute Myeloid Leukaemia

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